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Job Details

Location
Waltham
Salary
Competitive Salary
Job Type
Permanent
Ref
BH-177676
Contact
Yin Yin Pui
Contact email
Email Yin
Contact phone
+65 6692 0751
Posted
25 days ago
About the Role
This is an individual contributor role. You will provide formulation strategies that improve the product profile for mRNA vaccines and therapeutics for the company.

Responsibilities:
  • Handle formulation optimization related innovations to enhance mRNA stability using automation, in vitro / in vivo, and biophysical characterization to guide outcomes
  • Develop and drive pharmaceutical lyophilization process from bench to pilot scale in a global environment
  • Lead the development of product knowledge and understanding to nominate and identify key quality attributes and process parameters
  • Partner with CRO vendors to evaluate in vivo studies, process related activities, and analytical assessment of materials

Requirements:
  • PhD or Master in related disciplines (Pharmaceutical Sciences, Chemistry, Chemical Engineering, Bioengineering, etc) with hands on exposure in formulation and lyophilization work mandatory (1+ year) involving nucleic acid vaccines, sub-unit protein vaccines, biologics
  • Liposomal vehicle experience advantageous: LNP / lipids on formulation at laboratory / wet bench environment
  • Experience in Lyo-cycle process development and buffer and excipient selection using relevant statistical optimization methods (e.g. DoE)
  • Familiarity with analytical techniques a plus (e.g. HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry, high-throughput sequences)
  • Awareness of regulatory guidelines to support the drafting of analytical strategies for RNA-focused discovery programs and early-development translation efforts
  • CRO Management in the lyophilization and formulation space


BeathChapman Pte Ltd